The v-abl tyrosine kinase negatively regulates NF-kappa B/Rel factors and blocks kappa gene transcription in pre-B lymphocytes.
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چکیده
منابع مشابه
T suppressor lymphocytes inhibit NF-kappa B-mediated transcription of CD86 gene in APC.
CD8+CD28- human T suppressor cells (Ts) act on APC, inhibiting their ability to elicit Th activation and proliferation. This effect is due to inhibition of the CD40 pathway which normally leads to CD80 and CD86 up-regulation. To determine whether Ts inhibit expression of B7 molecules by blocking transcription, we cloned and characterized the CD86 promoter. Mutational analysis revealed that Ts i...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 1994
ISSN: 0890-9369
DOI: 10.1101/gad.8.6.678